J Orofac Pain 30 (2016), No. 4 28. Oct. 2016
J Orofac Pain 30 (2016), No. 4 (28.10.2016)
Characterization of Burning Mouth Syndrome in Patients with Parkinson's Disease
Bonenfant, David / Rompré, Pierre H. / Rei, Nathalie / Jodoin, Nicolas / Soland, Valerie Lynn / Rey, Veronica / Brefel-Courbon, Christine / Ory-Magne, Fabienne / Rascol, Olivier / Blanchet, Pierre J.
Aims: To determine the prevalence and characteristics of burning mouth syndrome (BMS) in a Parkinson's disease (PD) population through a selfadministered, custom-made survey.
Methods: A total of 218 surveys were collected during regular outpatient visits at two Movement Disorders Clinics in Montreal (Canada) and Toulouse (France) to gather information about pain experience, PD-related symptoms, and oral and general health. A neurologist confirmed the diagnosis of PD, drug treatment, Hoehn-Yahr stage, and Schwab & England Activity of Daily Living score. Data between groups were compared using the independent samples Mann-Whitney U test and two-sided exact Fisher test.
Results: Data from 203 surveys were analyzed. BMS was reported by eight subjects (seven females and one male), resulting in a prevalence of 4.0% (95% confidence interval [CI] = 2.1-7.8). Five participants with chronic nonburning oral pain were excluded. PD severity and levodopa equivalent daily dose did not differ between non-BMS and BMS participants. Mean poor oral health index was higher in BMS compared to non-BMS subjects (49.0 vs 32.2 points, P < .05). BMS manifested after PD onset in seven patients, did not occur on a daily basis in four, and always coexisted with restless legs syndrome.
Conclusion: This survey yielded a low prevalence of BMS in PD patients, indicating no strong link between the two conditions. An augmenting effect such as that resulting from drug treatment in restless legs syndrome or sensory neuropathy cannot be excluded.
Keywords: burning mouth syndrome, oral pain, Parkinson's disease